Akusherstvo i ginekologiia · 1999
[The treatment of hirsutism in adolescent girls with spironolactone].
Клиническое исследованиеСравнительное исследованиеАннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Malinova M
Аннотация
OBJECTIVE: The purpose of this study was to determine the antiandrogenic properties of spironolactone on hirsute adolescents.
MATERIAL AND METHODS: Thirty-four adolescents between 15-18 years were studied. The hirsute adolescents were treated with spironolactone from 4th to the 22d day of the menstrual cycle for 8 months.
RESULTS: Clinical improvement became evident usually 3 months after initiation of treatment. After 8 months, hirsutism has improved in 24 (70.6%) of 34 adolescents. A decrease in testosterone levels occurred in all patients, even those with initially normal values.
CONCLUSIONS: The encouraging results obtained with spironolactone suggest that it may proved to be the appropriate drug for treatment of hirsute adolescents.
MATERIAL AND METHODS: Thirty-four adolescents between 15-18 years were studied. The hirsute adolescents were treated with spironolactone from 4th to the 22d day of the menstrual cycle for 8 months.
RESULTS: Clinical improvement became evident usually 3 months after initiation of treatment. After 8 months, hirsutism has improved in 24 (70.6%) of 34 adolescents. A decrease in testosterone levels occurred in all patients, even those with initially normal values.
CONCLUSIONS: The encouraging results obtained with spironolactone suggest that it may proved to be the appropriate drug for treatment of hirsute adolescents.