Association Between SNPs (rs1533428, rs12994401, rs10202118) on chromosome 2p16.3 and primary open angle glaucoma.

AIMS: A meta-analysis was conducted to evaluate the association of rs1533428, rs12994401, rs10202118 polymorphism on chromosome 2p16.3 with POAG susceptibility.

METHODS

Systematic searches were performed on the electronic databases, the Cochrane Central Register of Controlled Trials, PubMed, ISI Web of Knowledge (Version 4.5), Chinese national knowledge infrastructure (CNKI), and Wanfang (Chinese) before March 2014. Overall and subgroup analyses were performed. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the strength of associations. Heterogeneity and Sensitivity analysis was also performed.

RESULTS

Seven published articles with 25 datasets were included in the meta-analysis. The overall results showed no evidence for significant association of rs1533428, rs12994401, rs10202118 polymorphism with POAG risk in allelic model (rs1533428: OR = 1.23 [1.01, 1.49], p = 0.03; rs12994401: OR = 1.32 [0.96, 1.81], p = 0.08; rs10202118: OR = 0.95 [0.76, 1.20], p = 0.68), and similar results were obtained in the dominant, additive and the recessive models and subgroup analysis based on the ethnicity.

CONCLUSIONS

Our study indicated that rs1533428, rs12994401, rs10202118 polymorphism on chromosome 2p16.3 might not be a risk factor for POAG. Further studies with well-designed among different ethnicity populations are required.