Journal of cellular biochemistry · 2019
Molecular evidence of role of vitamin D deficiency in various extraskeletal diseases.
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Zendehdel Abolfazl, Arefi Mohammad
Аннотация
BACKGROUND: Role of vitamin D is not only limited to skeletal system but various other systems of the body, such as immune system, endocrine system, and cardiopulmonary system.
MATERIALS AND METHODS: It is supported by the confirmations of systems-wide expression of vitamin D receptor (VDR), endocrinal effect of calcitriol, and its role in immune responses.
RESULTS: Expression of VDR in various systems, immunoregulatory and hormonal response of vitamin D and deficiency of vitamin D may establish various pathologies in the body.
CONCLUSION: This review provides molecular evidence of relation of vitamin D with extra skeletal.
MATERIALS AND METHODS: It is supported by the confirmations of systems-wide expression of vitamin D receptor (VDR), endocrinal effect of calcitriol, and its role in immune responses.
RESULTS: Expression of VDR in various systems, immunoregulatory and hormonal response of vitamin D and deficiency of vitamin D may establish various pathologies in the body.
CONCLUSION: This review provides molecular evidence of relation of vitamin D with extra skeletal.