Molecular evidence of role of vitamin D deficiency in various extraskeletal diseases.

BACKGROUND

Role of vitamin D is not only limited to skeletal system but various other systems of the body, such as immune system, endocrine system, and cardiopulmonary system.

MATERIALS AND

METHODS

It is supported by the confirmations of systems-wide expression of vitamin D receptor (VDR), endocrinal effect of calcitriol, and its role in immune responses.

RESULTS

Expression of VDR in various systems, immunoregulatory and hormonal response of vitamin D and deficiency of vitamin D may establish various pathologies in the body.

CONCLUSION

This review provides molecular evidence of relation of vitamin D with extra skeletal.