The effectiveness of levamisole hydrochloride in the treatment of adult Dirofilaria immitis.

Dogs infected with D. immitis were treated with oral levamisole hydrochloride at various dose rates over different durations. Clinical toxicity, haematological and biochemical parameters, body weight and food intake were recorded and filarial mortality estimated at autopsy. All filariae were dead in dogs treated at 10 mg/kg body weight twice daily (12 hourly) for 14 days, with minimal clinical toxicity being seen during the treatment period.