Journal of biochemical and molecular toxicology · 2026
Multifaceted Exploration of a New Schiff Base and Its Complexes: Thermal Properties and Biomedical Potential.
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Thakor Priteshkumar M, Patel Jatin D, Patel Rajesh J, Chaki Sunil H, Khimani Ankurkumar J, Vaidya Yati H, Raol Gopalkumar G, Thakor Parth, Thakkar Anjali B
Аннотация
This study presents the thermal and biomedical evaluation of a newly synthesized imine ligand and its six metal complexes. The synthesis and spectral data are detailed in Part 1 of this work. Here, advanced analyses such as LC-MS, SEM, and XRD were used for physicochemical characterization. Thermal stability was assessed using TGA, DTA, and DTG under inert conditions, with kinetic parameters calculated via the Kissinger-Akahira-Sunose method. Biological evaluations included molecular docking, which showed notable α-amylase inhibition, and MTT assays, which confirmed strong anticancer activity against A549 lung cancer cells. Additionally, the ligand and its complexes demonstrated anti-Alzheimer's and stress-resistance effects in Caenorhabditis elegans.