New Therapeutic Options Against Clinically Relevant Proteases in Cancer Progression.

Proteases are key regulators in cancer progression and metastasis, representing promising therapeutic targets. This review underscores the critical role of diverse proteases-encompassing cell surface ectoproteases, extracellular proteases, and intracellular proteases-in tumor biology, with a focus on the most significant and clinically relevant ones. Their overexpression in tumors reflects their importance in cancer development, invasion, and drug resistance. Emerging research has unveiled novel strategies to target proteases for cancer therapy, offering hope for improved treatment outcomes. However, challenges, such as selectivity, drug delivery, and toxicity remain significant hurdles to overcome. This article discusses current advancements, challenges, and future opportunities in targeting proteases for cancer therapy.