European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2025
Impact of COVID-19 on neoadjuvant chemotherapy efficacy in patients with breast cancer: An ambidirectional cohort study and mendelian randomization analysis.
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Wang Yali, Zhan Jiaqi, Liu Shunyi, Chen Minyan, Chen Lili, Lin Yuxiang, Hou Jialin, Yu Liuwen, Chen Xiaobin, Cai Weifeng, Qiu Yibin, Cai Qindong, He Peng, Guo Wenhui, Xu Chunsen, Lin Shunguo, Fu Fangmeng, Wang Chuan
Аннотация
INTRODUCTION: Patients with breast cancer are susceptible to coronavirus disease (COVID-19), which affects cancer treatment efficacy and prognosis. However, its effects on neoadjuvant chemotherapy (NAC) response and its genetic correlation with breast cancer remain unclear. We aimed to clarify these effects and investigate potential genetic associations and shared pathogenic mechanisms.
MATERIALS AND METHODS: In this ambidirectional (retrospective and prospective) cohort study involving 856 breast cancer patients receiving NAC, with and without COVID-19, we evaluated the impact of COVID-19 on NAC response using multivariable logistic regression and three matching methods: propensity score matching, inverse probability of treatment weighting, and overlap weighting. Using single-cell and bulk transcriptome data from the Gene Expression Omnibus and genetic variants from the Genome-Wide Association Study databases, we conducted Mendelian randomization (MR) analysis to explore the core cellular subsets, shared genes, causal relationships, and common pathogenic mechanisms between COVID-19 and breast cancer.
RESULTS: Patients with breast cancer and COVID-19 showed poor NAC responses, including a low objective response rate and reduced likelihood of achieving RCB class 0-I in the HR+/HER2+ subgroup (OR = 0.46, P = 0.028, P for interaction = 0.024). The consistent findings from the three matching models support these results. Integrating single-cell and bulk transcriptome data with MR analyses revealed genetic correlations between COVID-19 and breast cancer and identified ABLIM1 and GZMM as potential genes linked to NAC resistance.
CONCLUSION: SARS-CoV-2 infection during NAC may compromise therapeutic efficacy in patients with breast cancer. ABLIM1 and GZMM may be causal genes in the genetic correlation between COVID-19 and breast cancer.
TRIAL REGISTRATION: This study received retrospective registration and approval from the Ethics Committee of Fujian Medical University Union Hospital (Ethical Committee Approval No. 2024KY232).
MATERIALS AND METHODS: In this ambidirectional (retrospective and prospective) cohort study involving 856 breast cancer patients receiving NAC, with and without COVID-19, we evaluated the impact of COVID-19 on NAC response using multivariable logistic regression and three matching methods: propensity score matching, inverse probability of treatment weighting, and overlap weighting. Using single-cell and bulk transcriptome data from the Gene Expression Omnibus and genetic variants from the Genome-Wide Association Study databases, we conducted Mendelian randomization (MR) analysis to explore the core cellular subsets, shared genes, causal relationships, and common pathogenic mechanisms between COVID-19 and breast cancer.
RESULTS: Patients with breast cancer and COVID-19 showed poor NAC responses, including a low objective response rate and reduced likelihood of achieving RCB class 0-I in the HR+/HER2+ subgroup (OR = 0.46, P = 0.028, P for interaction = 0.024). The consistent findings from the three matching models support these results. Integrating single-cell and bulk transcriptome data with MR analyses revealed genetic correlations between COVID-19 and breast cancer and identified ABLIM1 and GZMM as potential genes linked to NAC resistance.
CONCLUSION: SARS-CoV-2 infection during NAC may compromise therapeutic efficacy in patients with breast cancer. ABLIM1 and GZMM may be causal genes in the genetic correlation between COVID-19 and breast cancer.
TRIAL REGISTRATION: This study received retrospective registration and approval from the Ethics Committee of Fujian Medical University Union Hospital (Ethical Committee Approval No. 2024KY232).