Terapevticheskii arkhiv · 2005
[Low ability of blood lymphocytes to produce interferon-gamma in patients with idiopathic prolapse of mitral valve].
Аннотация на английскомСтатьяНазвание и аннотация: Оригинал на русском
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Surkina I D, Gurevich K G, Mel'nik O O, Akatova E V, Stepura O B, Pak L S, Martynov A I
Аннотация
AIM: To examine lymphocyte ability to synthetize interferon-gamma in patients with mitral prolapse (MP).
MATERIAL AND METHODS: The diagnosis of MP was made in 75 patients at echocardiography. ECG monitoring was made and the study of the ability of blood lymphocytes to produce IFN-gamma (If-g).
RESULTS: The ability to produce If-g was diminished. This phenomenon is associated with chronic inflammation, autonomic disregulation of cardiac activity, depends on gender.
CONCLUSION: Cytokine modulates metabolism of connective tissue in MP so If-g may participate in MP pathogenesis. Therefore, If-g and/or its inductors may prevent some MP-related complications due to its deficiency.
MATERIAL AND METHODS: The diagnosis of MP was made in 75 patients at echocardiography. ECG monitoring was made and the study of the ability of blood lymphocytes to produce IFN-gamma (If-g).
RESULTS: The ability to produce If-g was diminished. This phenomenon is associated with chronic inflammation, autonomic disregulation of cardiac activity, depends on gender.
CONCLUSION: Cytokine modulates metabolism of connective tissue in MP so If-g may participate in MP pathogenesis. Therefore, If-g and/or its inductors may prevent some MP-related complications due to its deficiency.