Antidepressant effect of vagal nerve stimulation in epilepsy patients: a systematic review.
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Assenza Giovanni, Tombini Mario, Lanzone Jacopo, Ricci Lorenzo, Di Lazzaro Vincenzo, Casciato Sara, Morano Alessandra, Giallonardo Anna Teresa, Di Bonaventura Carlo, Beghi Ettore, Ferlazzo Edoardo, Gasparini Sara, Giuliano Loretta, Pisani Francesco, Benna Paolo, Bisulli Francesca, De Falco Fabrizio A, Franceschetti Silvana, La Neve Angela, Meletti Stefano, Mostacci Barbara, Sartucci Ferdinando, Striano Pasquale, Villani Flavio, Aguglia Umberto, Avanzini Giuliano, Belcastro Vincenzo, Bianchi Amedeo, Cianci Vittoria, Labate Angelo, Magaudda Adriana, Michelucci Roberto, Verri Annapia, Zaccara Gaetano, Pizza Vincenzo, Tinuper Paolo, Di Gennaro Giancarlo, Epilepsy Study Group of the Italian Neurological Society
Аннотация
MATERIAL AND METHODS: A comprehensive search of PubMed, Medline, Scopus, and Google Scholar was performed, and results were included up to January 2020. All studies concerning depressive symptom assessment in epileptic patients treated with VNS were included.
RESULTS: Nine studies were included because they fulfilled inclusion criteria. Six out of nine papers reported a positive effect of VNS on depressive symptoms. Eight out of nine studies did not find any correlation between seizure reduction and depressive symptom amelioration, as induced by VNS. Clinical scales for depression, drug regimens, and age of patients were broadly different among the examined studies.
CONCLUSIONS: Reviewed studies strongly suggest that VNS ameliorates depressive symptoms in drug-resistant epileptic patients and that the VNS effect on depression is uncorrelated to seizure response. However, more rigorous studies addressing this issue are encouraged.