Annals of medicine and surgery (2012) · 2026
Causal association between gastroesophageal reflux disease and anemia: Mendelian randomization analysis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tusuntuoheti Yusujiang, Maimaitiming Maimaitiaili, Huang Xudong, Zhou Zheqi, Wen Jiaxin, Abudureyimu Kelimu, Aili Aikebaier
Аннотация
BACKGROUND: Previous observational studies have indicated a possible link between gastroesophageal reflux disease (GERD) and anemia, but the causal relationships and specific anemia subtypes involved remain unclear.
METHODS: To explore the causal relationship between GERD and anemia risk, we conducted a two-sample Mendelian randomization study using the inverse-variance weighting (IVW) analytical method. After stringent selection, 75 and 76 independent single nucleotide polymorphisms were used as instrumental variables for GERD in analyses of anemia and iron-deficiency anemia (IDA), respectively.
RESULTS: IVW analysis demonstrated that genetically predicted GERD was associated with elevated anemia [odds ratios (OR) = 1.35; 95% confidence interval (CI): 1.17-1.56, P < 0.001] or IDA risk (OR = 1.30; 95% CI: 1.18-1.42; P < 0.001). The results of the weighted median analysis were also consistent with those of the IVW analysis and provided evidence of causal links (P < 0.05). However, the sensitivity analyses revealed no evidence of horizontal pleiotropy or heterogeneity.
CONCLUSIONS: Our study provides evidence consistent with a causal relationship between GERD and an elevated risk of developing anemia or IDA. However, because all GWAS datasets used in this study were derived from individuals of European ancestry, the generalizability of our findings to other populations remains uncertain and requires confirmation in diverse ethnic groups.
METHODS: To explore the causal relationship between GERD and anemia risk, we conducted a two-sample Mendelian randomization study using the inverse-variance weighting (IVW) analytical method. After stringent selection, 75 and 76 independent single nucleotide polymorphisms were used as instrumental variables for GERD in analyses of anemia and iron-deficiency anemia (IDA), respectively.
RESULTS: IVW analysis demonstrated that genetically predicted GERD was associated with elevated anemia [odds ratios (OR) = 1.35; 95% confidence interval (CI): 1.17-1.56, P < 0.001] or IDA risk (OR = 1.30; 95% CI: 1.18-1.42; P < 0.001). The results of the weighted median analysis were also consistent with those of the IVW analysis and provided evidence of causal links (P < 0.05). However, the sensitivity analyses revealed no evidence of horizontal pleiotropy or heterogeneity.
CONCLUSIONS: Our study provides evidence consistent with a causal relationship between GERD and an elevated risk of developing anemia or IDA. However, because all GWAS datasets used in this study were derived from individuals of European ancestry, the generalizability of our findings to other populations remains uncertain and requires confirmation in diverse ethnic groups.