Emerging microbes & infections · 2018
Novel triple-reassortant influenza viruses in pigs, Guangxi, China.
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He Ping, Wang Guojun, Mo Yanning, Yu Qingxiong, Xiao Xiong, Yang Wenjuan, Zhao Weifeng, Guo Xuan, Chen Qiong, He Jianqiao, Liang Mingli, Zhu Jian, Ding Yangbao, Wei Zuzhang, Ouyang Kang, Liu Fang, Jian Hui, Huang Weijian, García-Sastre Adolfo, Chen Ying
Аннотация
Considered a "mixing vessel" for influenza viruses, pigs can give rise to new influenza virus reassortants that can threaten humans. During our surveillance of pigs in Guangxi, China from 2013 to 2015, we isolated 11 H1N1 and three H3N2 influenza A viruses of swine origin (IAVs-S). Out of the 14, we detected ten novel triple-reassortant viruses, which contained surface genes (hemagglutinin and neuraminidase) from Eurasian avian-like (EA) H1N1 or seasonal human-like H3N2, matrix (M) genes from H1N1/2009 pandemic or EA H1N1, nonstructural (NS) genes from classical swine, and the remaining genes from H1N1/2009 pandemic. Mouse studies indicate that these IAVs-S replicate efficiently without prior adaptation, with some isolates demonstrating lethality. Notably, the reassortant EA H1N1 viruses with EA-like M gene have been reported in human infections. Further investigations will help to assess the potential risk of these novel triple-reassortant viruses to humans.