Journal of child and adolescent psychopharmacology · 2010
Neurobiological substrates of Tourette's disorder.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАОбзорНазвание и аннотация: Перевод пока не подготовлен
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Leckman James F, Bloch Michael H, Smith Megan E, Larabi Daouia, Hampson Michelle
Аннотация
OBJECTIVE: This article reviews the available scientific literature concerning the neurobiological substrates of Tourette's disorder (TD).
METHODS: The electronic databases of PubMed, ScienceDirect, and PsycINFO were searched for relevant studies using relevant search terms.
RESULTS: Neuropathological as well as structural and functional neuroimaging studies of TD implicate not only the sensorimotor corticostriatal circuit, but also the limbic and associative circuits as well. Preliminary evidence also points to abnormalities in the frontoparietal network that is thought to maintain adaptive online control. Evidence supporting abnormalities in dopaminergic and noradrenergic neurotransmission remains strong, although the precise mechanisms remain the subject of speculation.
CONCLUSION: Structural and functional abnormalities in multiple parallel corticostriatal circuits may underlie the behavioral manifestations of TD and related neuropsychiatric disorders over the course of development. Further longitudinal research is needed to elucidate these neurobiological substrates.
METHODS: The electronic databases of PubMed, ScienceDirect, and PsycINFO were searched for relevant studies using relevant search terms.
RESULTS: Neuropathological as well as structural and functional neuroimaging studies of TD implicate not only the sensorimotor corticostriatal circuit, but also the limbic and associative circuits as well. Preliminary evidence also points to abnormalities in the frontoparietal network that is thought to maintain adaptive online control. Evidence supporting abnormalities in dopaminergic and noradrenergic neurotransmission remains strong, although the precise mechanisms remain the subject of speculation.
CONCLUSION: Structural and functional abnormalities in multiple parallel corticostriatal circuits may underlie the behavioral manifestations of TD and related neuropsychiatric disorders over the course of development. Further longitudinal research is needed to elucidate these neurobiological substrates.