Unraveling the Mystery: A Case Report of Erythrodermic Psoriasis as an Adverse Reaction to Wellbutrin.

Understanding unintentional and adverse reactions to medications is key in pharmacologic therapy. These adverse effects can range from mild, well-tolerated symptoms to detrimental consequences for the patient. These symptoms can also range in terms of organ system involvement, some of which may be isolated to only the skin, while others can create end-organ damage and involve multiple systems. Psoriasis, a common inflammatory skin condition, can also be found as an adverse reaction to medications, particularly bupropion, also known as Wellbutrin. We present a rare finding of biopsy-proven erythrodermic psoriasis (EP) in a 40-year-old female with no previous history of psoriasis that occurred shortly after starting bupropion. This report highlights the importance of considering drug-induced adverse reactions in patients presenting with atypical dermatologic manifestations.