Dermatology practical & conceptual · 2025
Stem Cell Therapy: A New Approach and Effective Treatment for Psoriasis.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
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Saadh Mohamed J, Ahmed Hanan Hassan, Kareem Radhwan Abdul, Ballal Suhas, Sharma Shilpa, Guntaj J, Siva Prasad G V, Taher Waam Mohammed, Alwan Mariem, Jawad Mahmood Jasem, Hamad Atheer Khdyair
Аннотация
INTRODUCTION: The underlying mechanisms behind the development of psoriasis have become better understood in recent years. Key factors involved include the heightened reactivity of certain T cell subsets (Th1 and Th17 cells) as well as dysregulation of regulatory T cell (T-reg) function. Additionally, the complex interplay between immune cells, skin cells (keratinocytes), and the blood vessel endothelium has been shown to play an important role in the pathogenesis of psoriasis.
OBJECTIVES: A more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.
METHODS: In this study, we reviewed the evidence regarding the role played by stem cells in the pathogenesis of psoriasis as well as initial attempts at leveraging stem cells as a treatment modality.
RESULTS: Investigations uncovered the impact that epidermal stem cells and their interactions with T cells have in psoriasis. Importantly, malfunctions across diverse stem cell types may constitute a central mechanism underlying the dysregulated inflammatory processes that characterize this condition.
CONCLUSIONS: Nonetheless, a more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.
OBJECTIVES: A more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.
METHODS: In this study, we reviewed the evidence regarding the role played by stem cells in the pathogenesis of psoriasis as well as initial attempts at leveraging stem cells as a treatment modality.
RESULTS: Investigations uncovered the impact that epidermal stem cells and their interactions with T cells have in psoriasis. Importantly, malfunctions across diverse stem cell types may constitute a central mechanism underlying the dysregulated inflammatory processes that characterize this condition.
CONCLUSIONS: Nonetheless, a more thorough investigation of these mechanisms could present an opportunity to devise novel therapeutic approaches.