Eye (London, England) · 2026
Diabetes and uveitis. A large cohort evaluation of the association between glycaemic control and incident undifferentiated anterior uveitis. (The DULCE Study).
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Oliver Courtney, Gasquet Nicolas, Berkenstock Meghan K, Liberman Paulina
Аннотация
BACKGROUND/OBJECTIVES: To determine whether the risk of incident, undifferentiated, anterior uveitis increases with worsening glycaemic control.
SUBJECTS/METHODS: This retrospective, multicentre cohort study analysed 12,192,033 adults (>= 18 years) from the TriNetX database (2010-2023). Individuals with pre-existing uveitis or systemic inflammatory diseases were excluded. The primary outcome was the incidence of undifferentiated anterior uveitis. HbA1c was modelled both categorically (non-diabetic, well-controlled diabetes [<8.0%], poorly controlled diabetes [>= 8.0%]) and continuously. Cox proportional hazards regression estimated adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs); logistic regression modelled the continuous association.
RESULTS: Increasing HbA1c levels were strongly associated with incident uveitis (P < 0.001). Compared with non-diabetic controls, risk was elevated among patients with well-controlled diabetes (aHR 3.25; 95% CI 3.16-3.34) and further increased with poor control (aHR 4.07; 95% CI 3.95-4.19). For each 1% rise in HbA1c, the odds of developing uveitis increased by 10% (adjusted OR 1.10; 95% CI 1.10-1.11). Predicted probabilities rose non-linearly, reaching 1.11% at HbA1c 18%.
CONCLUSIONS: The risk of undifferentiated anterior uveitis increases with increasing HbA1c values.
SUBJECTS/METHODS: This retrospective, multicentre cohort study analysed 12,192,033 adults (>= 18 years) from the TriNetX database (2010-2023). Individuals with pre-existing uveitis or systemic inflammatory diseases were excluded. The primary outcome was the incidence of undifferentiated anterior uveitis. HbA1c was modelled both categorically (non-diabetic, well-controlled diabetes [<8.0%], poorly controlled diabetes [>= 8.0%]) and continuously. Cox proportional hazards regression estimated adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs); logistic regression modelled the continuous association.
RESULTS: Increasing HbA1c levels were strongly associated with incident uveitis (P < 0.001). Compared with non-diabetic controls, risk was elevated among patients with well-controlled diabetes (aHR 3.25; 95% CI 3.16-3.34) and further increased with poor control (aHR 4.07; 95% CI 3.95-4.19). For each 1% rise in HbA1c, the odds of developing uveitis increased by 10% (adjusted OR 1.10; 95% CI 1.10-1.11). Predicted probabilities rose non-linearly, reaching 1.11% at HbA1c 18%.
CONCLUSIONS: The risk of undifferentiated anterior uveitis increases with increasing HbA1c values.