Journal of cardiovascular pharmacology · 2020
Cardiovascular Considerations in Treating Patients With Coronavirus Disease 2019 (COVID-19).
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Dixon Dave L, Van Tassell Benjamin W, Vecchié Alessandra, Bonaventura Aldo, Talasaz Azita H, Kakavand Hessam, D'Ascenzo Fabrizio, Perciaccante Antonio, Castagno Davide, Ammirati Enrico, Biondi-Zoccai Giuseppe, Stevens Michael P, Abbate Antonio
Аннотация
A novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly across the globe since December 2019. Coronavirus disease 2019 (COVID-19) has a significantly higher mortality rate than seasonal influenza and has disproportionately affected older adults, especially those with cardiovascular disease and related risk factors. Adverse cardiovascular sequelae, such as myocarditis, acute myocardial infarction, and heart failure, have been reported in patients with COVID-19. No established treatment is currently available; however, several therapies, including remdesivir, hydroxychloroquine and chloroquine, and interleukin (IL)-6 inhibitors, are being used off-label and evaluated in ongoing clinical trials. Considering these therapies are not familiar to cardiovascular clinicians managing these patients, this review describes the pharmacology of these therapies in the context of their use in patients with cardiovascular-related conditions.