Annali italiani di chirurgia · 2007
[Postoperative follow-up of gastric adenocarcinoma with neoplastic markers and 18-FDG-PET/TC].
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Patriti Alberto, Graziosi Luigina, Baffa Nicodemo, Pacifico Eugenio, Lamprini Papaefthimiou, Valiani Saverio, Gullà Nino, Donini Annibale
Аннотация
INTRODUCTION: The usefulness of tumour markers CEA, CA19.9 and CA72.4 in association with FDG-PET/TC were prospectively evaluated in the post-operative follow-up of gastric cancer patients.
MATERIAL AND METHODS: Fifty one consecutive patients were enrolled in a follow-up programme entailing with periodical clinical evaluations, instrumental examinations and tumour markers assay FDG-PET/TC was performed only in cases of suspected recurrence.
RESULTS: Sensitivity of CEA, CA19.9 e CA72.4 during the follow-up period was respectively: 16%, 33.3% e 50%. Overall sensitivity was 66.6%. Specificity was 100% for CEA, 93.3% for CA19.9, 100% for CA72.4, with an overall specificity of 96.2%. FDG-PET/TC had a sensitivity of 100%.
CONCLUSIONS: Tumour markers in association with FDG-PET/TC allow an early identification of recurrences after surgery, with the advantage to start chemotherapy or surgical protocols before the tumour has reached an advanced stage.
MATERIAL AND METHODS: Fifty one consecutive patients were enrolled in a follow-up programme entailing with periodical clinical evaluations, instrumental examinations and tumour markers assay FDG-PET/TC was performed only in cases of suspected recurrence.
RESULTS: Sensitivity of CEA, CA19.9 e CA72.4 during the follow-up period was respectively: 16%, 33.3% e 50%. Overall sensitivity was 66.6%. Specificity was 100% for CEA, 93.3% for CA19.9, 100% for CA72.4, with an overall specificity of 96.2%. FDG-PET/TC had a sensitivity of 100%.
CONCLUSIONS: Tumour markers in association with FDG-PET/TC allow an early identification of recurrences after surgery, with the advantage to start chemotherapy or surgical protocols before the tumour has reached an advanced stage.
Предметные рубрики MeSH
AdenocarcinomaAgedAged, 80 and overAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorCA-19-9 AntigenCarcinoembryonic AntigenFemaleFluorodeoxyglucose F18Follow-Up StudiesGastrectomyHumansMaleMiddle AgedNeoplasm Recurrence, LocalPositron-Emission TomographyPostoperative PeriodProspective StudiesRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificityStomach NeoplasmsTomography, X-Ray Computed