Identifying research priorities for pituitary adenoma surgery: an international Delphi consensus statement.
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Newall Nicola, Valetopoulou Alexandra, Khan Danyal Z, Borg Anouk, Bouloux Pierre M G, Bremner Fion, Buchfelder Michael, Cudlip Simon, Dorward Neil, Drake William M, Fernandez-Miranda Juan C, Fleseriu Maria, Geltzeiler Mathew, Ginn Joy, Gurnell Mark, Harris Steve, Jaunmuktane Zane, Korbonits Márta, Kosmin Michael, Koulouri Olympia, Layard Horsfall Hugo, Mamelak Adam N, Mannion Richard, McBride Pat, McCormack Ann I, Melmed Shlomo, Miszkiel Katherine A, Raverot Gerald, Santarius Thomas, Schwartz Theodore H, Serrano Inma, Zada Gabriel, Baldeweg Stephanie E, Kolias Angelos G, Marcus Hani J, PitCop Collaborative
Аннотация
METHODS: An initial survey of patients, caregivers, and healthcare professionals assembled priorities related to preoperative care, surgical techniques, and postoperative management in pituitary surgery. Priorities were thematically grouped into summary priorities, and those answered by existing evidence were omitted following a literature review. An interim survey asked patients, caregivers, and healthcare professionals to select their top 10 priorities from the remaining list. The highest-ranked priorities advanced to a consensus meeting, where the top 10 questions were prioritized.
RESULTS: In the initial survey, 147 participants-60.5% of whom were patients, caregivers, or patient support group representatives-submitted 785 priorities, which were then condensed into 52 summary priorities. After a literature review, 33 unanswered priorities were included in the interim survey, completed by 155 respondents, of whom 54.2% were patients, caregivers, or patient support group representatives. The top-ranked priorities were discussed by 14 participants (7 patients and 7 healthcare professionals) during a consensus meeting. The top 10 priorities covered a variety of themes including enhancing diagnosis and management of pituitary adenomas, advancing surgical techniques and technologies, optimizing the prediction of outcomes and complications, and improving patient support and follow-up.
CONCLUSIONS: The top 10 research priorities in pituitary surgery aim to align researchers and direct funding in order to maximize impact and champion patient representation.