Alzheimer's & dementia (Amsterdam, Netherlands) · 2026
Alteration of glucose neurometabolism and brain morphology in mild behavioral impairment: a neuroimaging study on cognitively healthy individuals.
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Dolezal Rafael, Alzheimer's Disease Neuroimaging Initiative
Аннотация
INTRODUCTION: Regional brain enlargement and increased glucose neurometabolism do not normally indicate neurodegeneration. Mild behavioral impairment (MBI) occurring in cognitively healthy individuals, however, might be significantly affected by these processes.
METHODS: Three hundred forty-one cognitively normal individuals were analyzed using partial least squares (PLS) regression to determine neurometabolic and brain volumetric determinants of MBI scores. Radiolabeled glucose non-displaceable binding potential and volumes of Schaefer homooxygenation parcels were screened as regressors. PLS models were evaluated with cross-validation, scrambling, and bootstrapping.
RESULTS: Hypermetabolism in the left entorhinal cortex and hypertrophy in the left dorsal attention network B contribute substantially to the MBI total score. Significant morpho-functional interactions were observed between the right middle temporal cortex and the right salience-ventral attention B network.
DISCUSSION: MBI might depend on cerebral bioenergetic processes and morpho-functional interactions. Relative hypermetabolism and hypertrophy could be considered specific biomarkers of MBI indicating a prodromal maladaptive neural response.
METHODS: Three hundred forty-one cognitively normal individuals were analyzed using partial least squares (PLS) regression to determine neurometabolic and brain volumetric determinants of MBI scores. Radiolabeled glucose non-displaceable binding potential and volumes of Schaefer homooxygenation parcels were screened as regressors. PLS models were evaluated with cross-validation, scrambling, and bootstrapping.
RESULTS: Hypermetabolism in the left entorhinal cortex and hypertrophy in the left dorsal attention network B contribute substantially to the MBI total score. Significant morpho-functional interactions were observed between the right middle temporal cortex and the right salience-ventral attention B network.
DISCUSSION: MBI might depend on cerebral bioenergetic processes and morpho-functional interactions. Relative hypermetabolism and hypertrophy could be considered specific biomarkers of MBI indicating a prodromal maladaptive neural response.