Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2007
[Effects of systemic corticosteroids on expression of Eotaxin in nasal polyps].
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Yang Wu, Shi Wei, Chen Jinhui, Tao Zezhang
Аннотация
OBJECTIVE: To observe the effects of systemic corticosteroids on the expression of Eotaxin in nasal polyps.
METHOD: The SP immunohistochemical methods were applied to detected the expression of Eotaxin in nasal polyps before and after corticosteroids therapy. The optical density of positive cells in mucosal epithelia, vascular endothelia, inflammatory cells was measured by using HPIAS-2000 image-conduct system.
RESULT: The expression of Eotaxin was positive in the cytoplasm of the mucosal epithelia,the inflammatory cells and the vascular endothelia in nasal polyps. The expression of Eotaxin was significantly reduced in the mucosal epithelia, the inflammatory cells and the vascular endothelia of nasal polyps after treated with corticosteroids compared with pre-treated.
CONCLUSION: Inhibiting the expression of Eotaxin in mucosal epithelia, inflammatory cells and vascular endothelia of nasal polyps, reducing recruitment and activation of eosinophil and relieving eosinophil inflammatory reaction in nasal polyps may be one of mechanisms of systemic corticosteroids therapy on the nasal polyps.
METHOD: The SP immunohistochemical methods were applied to detected the expression of Eotaxin in nasal polyps before and after corticosteroids therapy. The optical density of positive cells in mucosal epithelia, vascular endothelia, inflammatory cells was measured by using HPIAS-2000 image-conduct system.
RESULT: The expression of Eotaxin was positive in the cytoplasm of the mucosal epithelia,the inflammatory cells and the vascular endothelia in nasal polyps. The expression of Eotaxin was significantly reduced in the mucosal epithelia, the inflammatory cells and the vascular endothelia of nasal polyps after treated with corticosteroids compared with pre-treated.
CONCLUSION: Inhibiting the expression of Eotaxin in mucosal epithelia, inflammatory cells and vascular endothelia of nasal polyps, reducing recruitment and activation of eosinophil and relieving eosinophil inflammatory reaction in nasal polyps may be one of mechanisms of systemic corticosteroids therapy on the nasal polyps.