Bulletin of experimental biology and medicine · 2019
Immunohistochemical Assessment of the Compensatory Responses in Rat Olfactory Bulbs after 6-Hydroxydopamine-Induced Lesion of the Substantia Nigra.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Voronkov D N, Khudoerkov R M, Sal'nikova O V, Stavrovskaya A V, Ol'shanskii A S, Gushchina A S
Аннотация
We assessed changes of olfactory bulbs in rata with 6-hydroxydopamine destruction of the substantia nigra. The expression of marker proteins of immature and differentiated neurons and glia (vimentin, PSA-NCAM, tyrosine hydroxylase, and S100) was analyzed by immunohistochemical and morphometric methods. The number of periglomerular dopamine neurons and astroglia in the olfactory bulbs increased on the side of toxin injection and expression of PSA-NCAM and vimentin increased in the rostral migratory stream. Destruction of the substantia nigra shifted differentiation of neuronal progenitors towards the dopaminergic phenotype and increased their survival in the olfactory bulbs, which can be explained by increased expression of PSA-NCAM.
Предметные рубрики MeSH
Adaptation, PhysiologicalAnimalsBiomarkersDisease Models, AnimalGene ExpressionHumansImmunohistochemistryInjections, IntraventricularMaleMotor ActivityNeural Cell Adhesion Molecule L1NeurogliaNeuronsOlfactory BulbOxidopamineParkinson Disease, SecondaryRatsRats, WistarS100 ProteinsSialic AcidsStereotaxic TechniquesSubstantia NigraTyrosine 3-MonooxygenaseVimentin