Utility of pan-immune-inflammation index in the diagnosis of masked hypertension in patients with type 2 diabetes mellitus.

BACKGROUND AND OBJECTIVE: Masked hypertension (MHT) is a specific pattern of hypertension (HT) wherein office BP is normal despite elevated BP measured using ambulatory blood pressure monitoring (ABPM). Pan-immune-inflammation value (PIV) is a novel inflammatory parameter with diagnostic and prognostic significance in a number of disease conditions. In this study, we aimed to investigate the diagnostic utility of PIV in MHT in outpatient clinic settings in seemingly normotensive patients with type 2 diabetes mellitus (T2DM). METHODS: We retrospectively included 78 MTH, 120 sustained hypertensive (SHT), and 176 normotensive patients with T2DM. 24 h-ABPM was used to detect MHT. PIV was calculated as neutrophil/lymphocyte x platelet x monocyte and compared between the groups. RESULTS: PIV was greater in MHT and SHT groups compared with the controls [310 (267–355), 353 (222.1-455.2) and 247.2 (195.3–340), respectively, p < 0.001). hs-CRP was found to be positively correlated with PIV. Logistic regression analysis showed that hs-CRP and PIV were independently associated with MHT. CONCLUSION: PIV and hs-CRP were independently associated with the presence of MHT. As a simple, inexpensive, and readily available parameter, PIV shows promise in the prediction of patients with MHT in T2DM patients.