The American journal of cardiology · 2018
Usefulness of Transcatheter Aortic Valve Implantation for Treatment of Pure Native Aortic Valve Regurgitation.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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De Backer Ole, Pilgrim Thomas, Simonato Matheus, Mackensen G Burkhard, Fiorina Claudia, Veulemanns Verena, Cerillo Alfredo, Schofer Joachim, Amabile Nicolas, Achkouty Guy, Schäfer Ulrich, Deutsch Marcus-André, Sinning Jan-Malte, Rahman Mohammed S, Sawaya Fadi J, Hildick-Smith David, Hernandez Jose Maria, Kim Won-Keun, Lefevre Thierry, Seiffert Moritz, Bleiziffer Sabine, Petronio Anna Sonia, Van Mieghem Nicolas, Taramasso Maurizio, Søndergaard Lars, Windecker Stephan, Latib Azeem, Dvir Danny
Аннотация
Patients with pure native aortic valve regurgitation (NAVR) and increased surgical risk are often denied surgery. This retrospective study aimed to evaluate the "off-label" use of transcatheter heart valves (THV) for the treatment of NAVR. A total of 254 high surgical risk patients with NAVR (age 74 ± 12 years, Society of Thoracic Surgeons risk score 6.6 ± 6.2%) underwent transcatheter aortic valve implantation (TAVI) with early generation (43%) or newer generation (57%) devices at 46 different sites. Device success was significantly higher in patients treated with newer as compared with early generation THV (82% vs 47%, p <0.001). The difference was driven by lower rates of device malpositioning (9% vs 33%) and aortic regurgitation (AR) ≥ moderate (4% vs 31%) and translated into higher clinical efficacy at 30 days in patients treated with newer as compared with early generation THV (72% vs 56%, p = 0.041). Both THV under- and oversizing were associated with an increased risk of THV malpositioning. In conclusion, TAVI is a feasible treatment strategy in selected high-risk patients with NAVR but is associated with a considerable risk of THV malpositioning and residual AR. Although newer-generation THV are associated with better outcomes, novel devices for the treatment of NAVR are warranted.