Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Cook Lawrence J, Rose John W, Alvey Jessica S, Jolley Anna Marie, Kuhn Renee, Marron Brie, Pederson Melissa, Enriquez Rene, Yearley Jeff, McKechnie Stephen, Han May H, Tomczak Anna J, Levy Michael, Mealy Maureen A, Coleman Jessica, Bennett Jeffrey L, Johnson Ruth, Barnes-Garcia Myka, Traboulsee Anthony L, Carruthers Robert L, Lee Lisa Eunyoung, Schubert Julia J, McMullen Katrina, Kister Ilya, Rimler Zoe, Reid Allyson, Sicotte Nancy L, Planchon Sarah M, Cohen Jeffrey A, Ivancic Diane, Sedlak Jennifer L, Sand Ilana Katz, Repovic Pavle, Amezcua Lilyana, Pruitt Ana, Amundson Erika, Chitnis Tanuja, Mullin Devin S, Klawiter Eric C, Russo Andrew W, Riley Claire S, Onomichi Kaho B, Levine Libby, Nelson Katherine E, Nealon Nancy M, Engel Casey, Kruse-Hoyer Mason, Marcille Melanie, Tornes Leticia, Rumpf Anne, Greer Angela, Kenneally Behne Megan, Rodriguez Renee R, Behne Daniel W, Blackway Derek W, Coords Brian, Blaschke Terrence F, Sheard Judy, Smith Terry J, Behne Jacinta M, Yeaman Michael R, Guthy-Jackson Charitable Foundation International Clinical Consortium (GJCF–ICC)
Аннотация
METHODS: To illustrate its research-enabling purpose, epidemiologic patterns and disease phenotypes were assessed among enrolled subjects, including age at disease onset, annualized relapse rate (ARR), and time between the first and second attacks.
RESULTS: As of December 2017, the Collaborative International Research in Clinical and Longitudinal Experience Study (CIRCLES) had enrolled more than 1,000 participants, of whom 77.5% of the NMOSD cases and 71.7% of the controls continue in active follow-up. Consanguineous relatives of patients with NMOSD represented 43.6% of the control cohort. Of the 599 active cases with complete data, 84% were female, and 76% were anti-AQP4 seropositive. The majority were white/Caucasian (52.6%), whereas blacks/African Americans accounted for 23.5%, Hispanics/Latinos 12.4%, and Asians accounted for 9.0%. The median age at disease onset was 38.4 years, with a median ARR of 0.5. Seropositive cases were older at disease onset, more likely to be black/African American or Hispanic/Latino, and more likely to be female.
CONCLUSIONS: Collectively, the CIRCLES experience to date demonstrates this study to be a useful and readily accessible resource to facilitate accelerating solutions for patients with NMOSD.