Journal of stomatology, oral and maxillofacial surgery · 2026
Benign HPV-associated oral, oropharyngeal and sinonasal lesions in anatomical and oral pathology laboratories in Mexico.
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Urias-Barreras Cynthia Marina, Rendón-Maldonado José Guadalupe, Villalobos-Rodelo Juan José, Ramón-Gallegos Eva, Rodríguez-Archilla Alberto
Аннотация
BACKGROUND: Human papillomavirus (HPV)-associated benign epithelial lesions often exhibit overlapping clinical and histopathological features, making differential diagnosis challenging.
OBJECTIVE: To investigate the clinicodemographic profiles of benign HPV-associated epithelial lesions diagnosed in anatomical and oral pathology laboratories.
METHODS: A retrospective cross-sectional study was conducted and included cases diagnosed between January 2014 and April 2023 in six pathology laboratories. Rendered diagnoses were squamous papilloma (SP), condyloma acuminatum (CA), verruca vulgaris (VV), multifocal epithelial hyperplasia (MEH), and sinonasal papilloma (SNP). Patient sex and age, and lesion site were recorded. For statistical analysis, the chi-square test (p < 0.05) was used.
RESULTS: A total of 113 cases were identified with 54.0% of them from anatomical pathology laboratories and 46.0% from oral pathology. Lesions were slightly more frequent in males (55.8%) and in patients ≤ 40 years (50.4%). SP was the most common diagnosis (71.7%). Tongue (28.4%) and oropharynx (23.3%) were the most frequently affected sites. Significant associations were observed between SP and patients ≤ 40 years (p = 0.003), CA and SNP with patients ≥ 41 years (p = 0.048 and p = 0.016, respectively), SP with the oropharynx (p = 0.001), and MEH with labial and buccal mucosa (p = 0.013). Lingual lesions were more frequent in women (p = 0.008), whereas oropharyngeal lesions predominated in men (p = 0.008).
CONCLUSIONS: Benign HPV-associated epithelial lesions demonstrate age- and sex-related anatomical predilections. Careful clinicopathological correlation remains essential for accurate diagnosis and appropriate management.
OBJECTIVE: To investigate the clinicodemographic profiles of benign HPV-associated epithelial lesions diagnosed in anatomical and oral pathology laboratories.
METHODS: A retrospective cross-sectional study was conducted and included cases diagnosed between January 2014 and April 2023 in six pathology laboratories. Rendered diagnoses were squamous papilloma (SP), condyloma acuminatum (CA), verruca vulgaris (VV), multifocal epithelial hyperplasia (MEH), and sinonasal papilloma (SNP). Patient sex and age, and lesion site were recorded. For statistical analysis, the chi-square test (p < 0.05) was used.
RESULTS: A total of 113 cases were identified with 54.0% of them from anatomical pathology laboratories and 46.0% from oral pathology. Lesions were slightly more frequent in males (55.8%) and in patients ≤ 40 years (50.4%). SP was the most common diagnosis (71.7%). Tongue (28.4%) and oropharynx (23.3%) were the most frequently affected sites. Significant associations were observed between SP and patients ≤ 40 years (p = 0.003), CA and SNP with patients ≥ 41 years (p = 0.048 and p = 0.016, respectively), SP with the oropharynx (p = 0.001), and MEH with labial and buccal mucosa (p = 0.013). Lingual lesions were more frequent in women (p = 0.008), whereas oropharyngeal lesions predominated in men (p = 0.008).
CONCLUSIONS: Benign HPV-associated epithelial lesions demonstrate age- and sex-related anatomical predilections. Careful clinicopathological correlation remains essential for accurate diagnosis and appropriate management.