Journal of ginseng research · 2026
Protopanaxatriol enhances mucin expression in intestinal epithelial cells and mice.
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Hu Yeye, He Ziliang, Dai Weijie, Hu Xuejunlan, Hu Haiyue, Wang Yuhao, Huang Lei, Mou Canglang, Su Jinghan, Wei Weizhaole, Wu Haifeng, You Long, Wang Honggang, Cho Jae Youl, Hu Weicheng
Аннотация
BACKGROUND: Mucins are critical components of the intestinal mucus layer that protects the gut epithelium and maintains microbiota balance. Protopanaxatriol (PPT), an active metabolite derived from protopanaxatriol-type saponins, has shown promise in modulating gut health, but its effects on mucin expression remain poorly understood.
OBJECTIVE: This study aimed to investigate the effects of PPT on mucin expression in human intestinal epithelial Caco-2 cells and in a mouse model.
METHODS: Caco-2 cells were treated with different concentrations of PPT, and the expression of mucins was assessed via qRT-PCR and Western blot analysis. In parallel, mice were administered PPT orally, and tissues were collected for mucin quantification.
RESULTS: PPT treatment significantly upregulated mucin expression at both the mRNA and protein levels in Caco-2 cells. In vivo, mice administered with PPT exhibited significantly elevated mucin expression in the colon. In addition, PPT administration also induced mucin expression in both lung and stomach tissues.
CONCLUSION: PPT promoted mucin expression in human intestinal epithelial cells and in the gut of mice, suggesting their potential as natural agents for maintaining gut health and preventing intestinal disorders.
OBJECTIVE: This study aimed to investigate the effects of PPT on mucin expression in human intestinal epithelial Caco-2 cells and in a mouse model.
METHODS: Caco-2 cells were treated with different concentrations of PPT, and the expression of mucins was assessed via qRT-PCR and Western blot analysis. In parallel, mice were administered PPT orally, and tissues were collected for mucin quantification.
RESULTS: PPT treatment significantly upregulated mucin expression at both the mRNA and protein levels in Caco-2 cells. In vivo, mice administered with PPT exhibited significantly elevated mucin expression in the colon. In addition, PPT administration also induced mucin expression in both lung and stomach tissues.
CONCLUSION: PPT promoted mucin expression in human intestinal epithelial cells and in the gut of mice, suggesting their potential as natural agents for maintaining gut health and preventing intestinal disorders.