International journal of clinical oncology · 2026
Age-related prognostic trends in surgically resected female lymph node-metastatic gastric cancer: insights from SEER.
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Hu Bozhi, Zhang Yinli, Ye Yingjiang, Gao Zhidong, Wang Chao
Аннотация
BACKGROUND: Understanding the relationship between age and prognosis of female lymph node-metastatic gastric cancer (FLMGC) remains limited. This study aimed to elucidate the prognostic impact of age on FLMGC.
METHODS: This population-based retrospective analysis used data from the SEER database. After applying the exclusion criteria, a final cohort of 1,172 FLMGC cases was included. The patients were categorized by age into five groups: ≤ 50 years (n = 144), 51-60 years (n = 192), 61-70 years (n = 291), 71-80 years (n = 325), and ≥ 81 years (n = 220). Cancer-specific survival (CSS) was selected as the outcome in this study.
RESULTS: Significant factors for CSS identified in multivariate analysis included age, tumor differentiation, AJCC T and N stages, systemic therapy, number of positive lymph nodes, and total number of retrieved lymph nodes. Age had a nonlinear effect on CSS (P for nonlinearity < 0.001), with the lowest risk occurring in the 55-60 year age group.
CONCLUSIONS: This SEER-based study revealed a nonlinear relationship between age and FLMGC prognosis, with the lowest risk occurring in the 55-60-year age group.
METHODS: This population-based retrospective analysis used data from the SEER database. After applying the exclusion criteria, a final cohort of 1,172 FLMGC cases was included. The patients were categorized by age into five groups: ≤ 50 years (n = 144), 51-60 years (n = 192), 61-70 years (n = 291), 71-80 years (n = 325), and ≥ 81 years (n = 220). Cancer-specific survival (CSS) was selected as the outcome in this study.
RESULTS: Significant factors for CSS identified in multivariate analysis included age, tumor differentiation, AJCC T and N stages, systemic therapy, number of positive lymph nodes, and total number of retrieved lymph nodes. Age had a nonlinear effect on CSS (P for nonlinearity < 0.001), with the lowest risk occurring in the 55-60 year age group.
CONCLUSIONS: This SEER-based study revealed a nonlinear relationship between age and FLMGC prognosis, with the lowest risk occurring in the 55-60-year age group.