Investigative ophthalmology & visual science · 2003
Configuration of the optic chiasm in humans with albinism as revealed by magnetic resonance imaging.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Schmitz Bernd, Schaefer Torsten, Krick Christoph M, Reith Wolfgang, Backens Martin, Käsmann-Kellner Barbara
Аннотация
PURPOSE: To determine whether the size and configuration of the optic chiasm in humans with albinism is different from that in normal control subjects.
METHODS: Seventeen patients and 15 control subjects underwent magnetic resonance imaging of the entire head. Images were reformatted to the chiasm region and analyzed with observer-independent morphometry and measurements by a blinded observer.
RESULTS: The albino group showed significantly smaller chiasmatic widths, smaller optic nerves and tracts, and wider angles between nerves and tracts. Statistical morphometry showed a different configuration of the optic chiasm.
CONCLUSIONS: Size and configuration of the optic chiasm in humans with albinism are distinctly different from those in normal control subjects and reflect the atypical crossing of optic fibers.
METHODS: Seventeen patients and 15 control subjects underwent magnetic resonance imaging of the entire head. Images were reformatted to the chiasm region and analyzed with observer-independent morphometry and measurements by a blinded observer.
RESULTS: The albino group showed significantly smaller chiasmatic widths, smaller optic nerves and tracts, and wider angles between nerves and tracts. Statistical morphometry showed a different configuration of the optic chiasm.
CONCLUSIONS: Size and configuration of the optic chiasm in humans with albinism are distinctly different from those in normal control subjects and reflect the atypical crossing of optic fibers.