Genetic factors for idiopathic choroidal neovascularization.

Objective

The aim of this study was to investigate genetic factors associated with idiopathic choroidal neovascularization (ICNV).

Methods

We conducted a case-control study including 69 cases with ICNV and 114 controls who underwent cataract surgery. Single nucleotide polymorphisms (SNPs) from genes reported to be related to AMD, CNV and uveitis were selected for this study.

Results

In an univariate analysis, the rs669676 SNP located in the COL8A1 gene was associated with the proportion of people who has idiopathic CNV ( X2 = 9.3453, corrected p-value = 0.1). For the rs669676 SNP, minor allele homozygotes, in the dominant model of genotype analysis (GG versus AA-GA), it showed significant differences in the ICNV group vs controls (p = .01, OR = 1.219 (95%CI: 1.04-1.429)).

Conclusions

The rs669676 SNP located in the COL8A1 gene may contribute to a genetic susceptibility for ICNV.