European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2006
Lack of effect of acute dopamine precursor depletion in nicotine-dependent smokers.
Клиническое исследованиеСравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Casey Kevin F, Benkelfat Chawki, Young Simon N, Leyton Marco
Аннотация
RATIONALE: Nicotine increases dopamine (DA) release but its role in nicotine dependence remains unclear.
OBJECTIVE: To assess the role of DA in nicotine craving and self-administration using acute phenylalanine/tyrosine depletion (APTD).
METHODS: Fifteen nicotine-dependent men ingested, a minimum of 3days apart, a nutritionally balanced amino acid (AA) mixture (BAL), a mixture deficient in the catecholamine precursors, phenylalanine and tyrosine, and APTD followed by the immediate DA precursor, L-DOPA. Beginning 3h after ingestion of the AA mixture, subjects smoked 4 cigarettes. Craving, mood, and other aspects of subjective state were assessed with self-report scales. Smoking puff topography was measured with a computerized flowmeter.
RESULTS: APTD did not change smoking puff topography, cigarette craving, or subjective effects of smoking.
CONCLUSIONS: The findings suggest that in nicotine-dependent smokers craving for cigarettes, subjective effects of nicotine, and the self-administration of freely available cigarettes are largely unrelated to acute changes in DA neurotransmission.
OBJECTIVE: To assess the role of DA in nicotine craving and self-administration using acute phenylalanine/tyrosine depletion (APTD).
METHODS: Fifteen nicotine-dependent men ingested, a minimum of 3days apart, a nutritionally balanced amino acid (AA) mixture (BAL), a mixture deficient in the catecholamine precursors, phenylalanine and tyrosine, and APTD followed by the immediate DA precursor, L-DOPA. Beginning 3h after ingestion of the AA mixture, subjects smoked 4 cigarettes. Craving, mood, and other aspects of subjective state were assessed with self-report scales. Smoking puff topography was measured with a computerized flowmeter.
RESULTS: APTD did not change smoking puff topography, cigarette craving, or subjective effects of smoking.
CONCLUSIONS: The findings suggest that in nicotine-dependent smokers craving for cigarettes, subjective effects of nicotine, and the self-administration of freely available cigarettes are largely unrelated to acute changes in DA neurotransmission.