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Cell reports. Medicine · 2026

Proteogenomic analysis of pediatric and AYA high-grade glioma reveals age-dependent biology, female-male differences, and kinase targets.

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Tignor Nicole L, Koptyra Mateusz, Chowdhury Shrabanti, Petralia Francesca, Gritsenko Marina A, Ma Weiping, Zhu Yuankun, Marino Giacomo B, Song Xiaoyu, Migliozzi Simona, Whiteaker Jeffrey R, Rykunov Dmitry, Hu Yingwei, Hosseini Noshad, Rokita Jo Lynne, da Veiga Leprevost Felipe, Rathi Komal S, Chen Lijun, Wang Yi-Ting, Weitz Karl K, Chu Rosalie K, Moore Ronald J, Krek Azra, Fu Weijia, Wang Xuran, Deng Eden Z, Tsai Chia-Feng, Sagendorf Tyler, Petyuk Vladislav A, Shi Tujin, Fillmore Thomas L, Zhao Rui, Monroe Matthew E, Dannappel Marius V, Daniel Paul, Zhao Lei, Ivey Richard G, Voytovich Uliana J, Yaron-Barir Tomer M, Huntsman Emily M, Johnson Jared L, Abedin Nakib, Li Yan-Chak, Santi Mariarita, Dupal Demetri, Lilly Jena, Kraya Adam, Dybas Joseph M, Zhang Bo, Zhong Chuwei, Brown Miguel A, Phul Saksham, Wafula Eric, Farrel Alvin, Geng Zhuangzhuang, Corbett Ryan J, Naqvi Ammar S, Miller Daniel P, Mason Jennifer, Patton Tatiana S, McGrory Stephanie, Robins Shannon, Heath Allison, Sullivan Catherine, Coleman Noel, Morgan Allison, Garofano Luciano, Reva Boris, Schadt Eric E, Smith Richard D, Mesri Mehdi, Robles Ana I, Cantley Lewis C, Ding Li, Rodland Karin D, Zhang Bing, Nesvizhskii Alexey I, Iavarone Antonio, Cieslik Marcin, Ippolito Joseph E, Storm Phillip B, Rubin Joshua B, Firestein Ron, Ma'ayan Avi, Zhang Hui, Paulovich Amanda G, Liu Tao, Resnick Adam, Rood Brian R, Wang Pei, Philadelphia Coalition for a Cure, Children’s Brain Tumor Network, Clinical Proteomic Tumor Analysis Consortium

Аннотация

High-grade gliomas (HGGs) in children and adolescents and young adults (AYA) exhibit distinct biology across the neurodevelopmental spectrum. To dissect tumor-intrinsic molecular characteristics independent of developmental variation, we perform comprehensive proteogenomic analyses of tumors from 112 HGG patients aged 0-40 years. Our multi-omics analysis identifies two AYA subgroups-adolescents (aged 15-26 years) and young adults (aged 26-40 years)-with distinct molecular profiles and survival outcomes. Tumor-normal comparisons and survival modeling highlight roles of oxidative phosphorylation and neuronal system biology in glioma progression. Causal network analysis and cell line studies provide a rationale for personalized therapies targeting candidate kinases, such as CDK8. Survival modeling, clustering, and immune-landscape analyses identify proteins, post-translational modifications, and immune signatures linked to outcomes and reveal clinically relevant differences between male and female patients.

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

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