Frontiers in cellular and infection microbiology · 2026
Antifungal efficacy of a novel nitric oxide releasing solution in the presence of keratin.
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Long Lisa, Eltohky Ahmed, Sewake James, Miller Chris, Martins James, Teskey Simon J L, Ghannoum Mahmoud, McCormick Thomas S
Аннотация
INTRODUCTION: Nitric oxide (NO)-based therapeutics represent a promising modality for overcoming the challenges of treating dermatophyte infections within keratinized tissues.
METHODS: This study evaluated the antifungal activity of a nitric oxide-releasing solution (NORS) against clinical isolates of Trichophyton mentagrophytes, Trichophyton tonsurans, and Epidermophyton floccosum, comparing MIC and MFC profiles to efinaconazole and assessing keratin associated inhibition relative to terbinafine.
RESULTS: NORS demonstrated potent fungicidal activity across all species, with MIC90 and MFC90 values consistently at 0.005 μg/mL. Unlike terbinafine, whose efficacy decreased significantly in keratin-rich environments, NORS retained antifungal activity in the presence of human nail keratin.
DISCUSSION: These results support further clinical evaluation of NO-based antifungals as potential treatments for onychomycosis and tinea pedis.
METHODS: This study evaluated the antifungal activity of a nitric oxide-releasing solution (NORS) against clinical isolates of Trichophyton mentagrophytes, Trichophyton tonsurans, and Epidermophyton floccosum, comparing MIC and MFC profiles to efinaconazole and assessing keratin associated inhibition relative to terbinafine.
RESULTS: NORS demonstrated potent fungicidal activity across all species, with MIC90 and MFC90 values consistently at 0.005 μg/mL. Unlike terbinafine, whose efficacy decreased significantly in keratin-rich environments, NORS retained antifungal activity in the presence of human nail keratin.
DISCUSSION: These results support further clinical evaluation of NO-based antifungals as potential treatments for onychomycosis and tinea pedis.