Clinica chimica acta; international journal of clinical chemistry · 2025
Electrochemical biosensors for early detection of Alzheimer's disease.
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Matlyuba Jakhonkulovna Sanoeva, Bahodirova Kamolovna Gulnoz, Zokirov Muzaffar, Umida Tajimuratovna Babajanova, Yumashev Alexey, Shichiyakh Rustem, Safarova Nasiba I, Nargiza Nusratovna Aripova, Esanmuradova Nilufar, Muyassar Karimbaevna Tadjibaeva, Lazizakhon Alidjanova, Ishankulov Alisher
Аннотация
In recent years, electrochemical biosensors have shown great promise as innovative tools for the early identification of Alzheimer's disease (AD), a neurodegenerative disorder that severely affects cognitive ability and overall quality of life. This comprehensive review aims to consolidate the latest research on the creation and implementation of electrochemical biosensors designed to detect AD-related biomarkers. We examine cutting-edge approaches to surface modification that enhance the attachment of biorecognition molecules, thus enabling the simultaneous identification of multiple biomarkers. This review emphasizes the crucial role that electrochemical biosensors play in the early diagnosis of Alzheimer's disease, highlighting their potential to revolutionize clinical practices by facilitating timely interventions. In the future, research efforts should concentrate on refining these technologies for widespread clinical adoption, ensuring that they meet the needs of both healthcare professionals and patients.