[Effect of succinylation of Klebsiella 45 bacteriophage proteins on specific lytic activity].

Effect of different levels of virions protein acylation on lytic activity, parameters of interaction with sensitive bacterial cells and other biological properties of phages has been studied in experiments on Klebsiella 45 bacteriophage. It was shown that at 5-, 10- and 20% levels of the phage sample acylation the specific lytic activity increased 90, 12 and 8 times, respectively, adsorbtion velocity constant increased 9, 8 and 8 times, respectively, and latent period decreases by 20% in all cases of the development of productive infection caused by succinylated phages. Such chemical modification did not change morphology, antigenic structure of phase virions, did not take essential effect on the spectrum of lytic activity and average yield of infectious phage corpuscles per a sensitive bacterial cell.