Internal medicine (Tokyo, Japan) · 2022
Collagenous Colitis Possibly Associated with Dipeptidyl Peptidase-4 Inhibitor.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Takedomi Hironobu, Sakata Yasuhisa, Tomonaga Michito, Naruse Naomi, Yukimoto Takahiro, Akutagawa Takashi, Tsuruoka Nanae, Shimoda Ryo, Kido Shinichi, Esaki Motohiro
Аннотация
A 60-year-old man with type 2 diabetes mellitus treated with a dipeptidyl peptidase-4 (DPP-4) inhibitor was referred to our hospital because of his refractory watery diarrhea. Ileocolonoscopy revealed increased capillary growth, fine granular mucosa, and longitudinal mucosal tears mainly in the left side of the colon. A bioptic examination revealed thickened subepithelial collagen bands, thus confirming the diagnosis of collagenous colitis. Systemic steroid therapy was initiated, but his symptoms recurred when tapering the steroid. However, withdrawal of the DPP-4 inhibitor was successful even after the cessation of steroid therapy. We therefore considered his collagenous colitis to have been caused by the DPP-4 inhibitor.