BMC medical imaging · 2026
Spatially decoupled reliable mutual learning for semi-supervised medical image segmentation.
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Xie Anjie, Wang Chunmei, Zhang Haoyu, Li Zhiyuan, Zhu Liuhong, Zhou Jianjun
Аннотация
BACKGROUND: Semi-Supervised Learning reduces the annotation burden for medical image segmentation but currently suffers from spatial context overfitting and confirmation bias due to noisy pseudo-labels. This study aims to propose a robust framework to overcome these limitations.
METHODS: We introduce a novel framework termed Spatially Decoupled Reliable Mutual Learning (SDRML). To address context overfitting, we propose a Spatial Decoupling strategy that utilizes translation consistency, compelling the model to focus on intrinsic anatomical features rather than fixed background contexts. To mitigate confirmation bias, we design a Reliable Mutual Learning mechanism incorporating a Confident Regional Cross-entropy loss. This loss dynamically filters low-confidence predictions, ensuring only reliable pseudo-labels guide the tri-model co-training process.
RESULTS: Extensive experiments were conducted on the ACDC (2D MRI), Left Atrium (3D MRI), and Pancreas-CT datasets. SDRML significantly outperforms state-of-the-art methods across all benchmarks. Notably, it demonstrates superior robustness and segmentation accuracy in data-scarce scenarios, such as regimes with only 10% labeled data.
CONCLUSIONS: SDRML effectively resolves spatial dependency and noise accumulation issues in SSL. By leveraging spatial decoupling and reliable noise filtering, it provides a highly effective solution for medical image segmentation with limited annotations.
TRIAL REGISTRATION: Not applicable.
METHODS: We introduce a novel framework termed Spatially Decoupled Reliable Mutual Learning (SDRML). To address context overfitting, we propose a Spatial Decoupling strategy that utilizes translation consistency, compelling the model to focus on intrinsic anatomical features rather than fixed background contexts. To mitigate confirmation bias, we design a Reliable Mutual Learning mechanism incorporating a Confident Regional Cross-entropy loss. This loss dynamically filters low-confidence predictions, ensuring only reliable pseudo-labels guide the tri-model co-training process.
RESULTS: Extensive experiments were conducted on the ACDC (2D MRI), Left Atrium (3D MRI), and Pancreas-CT datasets. SDRML significantly outperforms state-of-the-art methods across all benchmarks. Notably, it demonstrates superior robustness and segmentation accuracy in data-scarce scenarios, such as regimes with only 10% labeled data.
CONCLUSIONS: SDRML effectively resolves spatial dependency and noise accumulation issues in SSL. By leveraging spatial decoupling and reliable noise filtering, it provides a highly effective solution for medical image segmentation with limited annotations.
TRIAL REGISTRATION: Not applicable.