[Design and development strategy for wearable and implantable artificial endocrine pancreas].

The ultimate goal of development of an artificial endocrine pancreas is for long-term strict glycemic control, and therefore, the trend in development is now from bedside-type to wearable- or implantable-type. With either a miniaturized extracorporeal glucose monitoring system based on microdialysis sampling method or a ferrocene-mediated needle-type glucose sensor covered with highly biocompatible membrane, and with subcutaneous insulin infusion algorithm using short-acting insulin analogue, long-term physiological glycemic control could be obtained by wearable artificial endocrine pancreas. The next step will be directed to the implantable one. Non-invasive infrared absorbance spectroscopy to fit into an artificial tooth prosthesis, an implantable artificial endocrine pancreas, in which measured glucose concentrations are transmitted telemetrically to implanted computer and pump system, might be developed.