Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
ΔR1blood, a surrogate of blood-pool gadolinium concentration, is related to body mass index, gender, left ventricular end-diastolic volume index, cardiac index, and field strength at cardiac magnetic resonance late enhancement imaging.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Doeblin Patrick, Ching Shing, Chen Wensu, Solowjowa Natalia, Werhahn Stefanie Maria, Beyer Rebecca Elisabeth, Estepa Misael, Stehning Christian, Li Jeffrey Ji-Peng, Dreger Henryk, Kelle Sebastian
Аннотация
BACKGROUND: Late gadolinium enhancement imaging is the cornerstone of tissue characterization via cardiac magnetic resonance imaging. The contrast-enhancing effect of gadolinium is caused by a linear increase in tissue longitudinal R1 relaxation rates (R1 = 1/T1). The change in R1 of blood pre- and post-contrast (ΔR1blood) is therefore a surrogate for the blood-pool gadolinium concentration, which in turn correlates linearly to the tissue gadolinium concentration. The total volume of distribution for gadolinium is the extracellular volume of the body, which differs with body composition, potentially leading to variations in blood-pool and tissue gadolinium concentrations.
METHODS: This study is a hypothesis-generating secondary analysis of a dataset of 1098 patients who underwent contrast cardiovascular magnetic resonance between August 2014 and November 2020 at a tertiary center. ΔR1blood was calculated from T1 relaxation time maps acquired before and approximately 15 min after application of 0.15 mmol/kg gadobutrol. Explorative data analysis and multiple linear regression were performed to assess the influence of body mass index (BMI), gender, age, cardiac index (CI), hematocrit (Hct), and left ventricular end-diastolic volume index (LVEDVi) on ΔR1blood.
RESULTS: In bivariate analysis, ΔR1blood showed moderate correlation to BMI and weak correlation to LVEDVi, Hct, and CI. The correlation to BMI was higher in women (r = 0.52 at 1.5T and r = 0.47 at 3T) than in men (r = 0.27 at 1.5T and r = 0.37 at 3T). Multiple linear regression showed independent predictive value of BMI, BMI:gender, gender, CI, field strength (FS), and LVEDVi (R² = 0.268, P < 0.001), with BMI remaining the strongest individual predictor (b = 0.032 [0.025; 0.040], η² = 0.13, P < 0.001).
CONCLUSION: ΔR1blood, a measurement of gadolinium contrast enhancement in the blood-pool and a surrogate of plasma CGd at the time of late enhancement imaging, showed moderate association with BMI, FS, and gender and weak association with LVEDVi and CI. Further research is necessary to assess the need for individualized gadolinium dosing.
METHODS: This study is a hypothesis-generating secondary analysis of a dataset of 1098 patients who underwent contrast cardiovascular magnetic resonance between August 2014 and November 2020 at a tertiary center. ΔR1blood was calculated from T1 relaxation time maps acquired before and approximately 15 min after application of 0.15 mmol/kg gadobutrol. Explorative data analysis and multiple linear regression were performed to assess the influence of body mass index (BMI), gender, age, cardiac index (CI), hematocrit (Hct), and left ventricular end-diastolic volume index (LVEDVi) on ΔR1blood.
RESULTS: In bivariate analysis, ΔR1blood showed moderate correlation to BMI and weak correlation to LVEDVi, Hct, and CI. The correlation to BMI was higher in women (r = 0.52 at 1.5T and r = 0.47 at 3T) than in men (r = 0.27 at 1.5T and r = 0.37 at 3T). Multiple linear regression showed independent predictive value of BMI, BMI:gender, gender, CI, field strength (FS), and LVEDVi (R² = 0.268, P < 0.001), with BMI remaining the strongest individual predictor (b = 0.032 [0.025; 0.040], η² = 0.13, P < 0.001).
CONCLUSION: ΔR1blood, a measurement of gadolinium contrast enhancement in the blood-pool and a surrogate of plasma CGd at the time of late enhancement imaging, showed moderate association with BMI, FS, and gender and weak association with LVEDVi and CI. Further research is necessary to assess the need for individualized gadolinium dosing.