Ophthalmology · 2012
Retinal vascular geometry and glaucoma: the Singapore Malay Eye Study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wu Renyi, Cheung Carol Yim-Lui, Saw Seang Mei, Mitchell Paul, Aung Tin, Wong Tien Yin
Аннотация
PURPOSE: To determine the associations of geometric measurements (tortuosity, branching angle, and fractal dimension) of retinal vessels with glaucoma.
DESIGN: Population-based, cross-sectional study.
PARTICIPANTS: Persons aged 40 to 80 years who participated in the Singapore Malay Eye Study (n=3280; 78.7% response rate).
METHODS: Quantitative retinal vascular parameters (tortuosity, branching angle, and fractal dimension) were measured from digital retinal fundus photographs using a computer-assisted program following a standardized grading protocol. Glaucoma was diagnosed according to the International Society of Geographic and Epidemiological Ophthalmology classification system.
MAIN OUTCOME MEASURES: The associations among retinal vascular parameters with glaucoma, the main glaucoma subtype primary open-angle glaucoma (POAG), and ocular hypertension (OHT).
RESULTS: A total of 123 persons (4.4% of the 2789 participants) had glaucoma in the final analysis, 87 (70.7%) of whom were diagnosed with POAG. After adjusting for age, sex, body mass index, diabetes, hypertension, smoking, axial length, and intraocular pressure (IOP), decreased retinal arteriolar tortuosity (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.38-2.18, comparing lowest vs. highest quartiles), decreased retinal venular tortuosity (OR, 1.59; 95% CI, 1.29-1.97), and narrower retinal venular branching angle (OR, 1.22; 95% CI, 1.00-1.48) were associated with glaucoma. Similar associations were found between these retinal vascular parameters and POAG. Decreased retinal vascular fractal dimension was associated with OHT (OR 1.37; 95% CI, 1.04-1.82).
CONCLUSIONS: Certain features of retinal vascular geometry are associated with glaucomatous optic neuropathy independently of vascular risk factors and IOP.
FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
DESIGN: Population-based, cross-sectional study.
PARTICIPANTS: Persons aged 40 to 80 years who participated in the Singapore Malay Eye Study (n=3280; 78.7% response rate).
METHODS: Quantitative retinal vascular parameters (tortuosity, branching angle, and fractal dimension) were measured from digital retinal fundus photographs using a computer-assisted program following a standardized grading protocol. Glaucoma was diagnosed according to the International Society of Geographic and Epidemiological Ophthalmology classification system.
MAIN OUTCOME MEASURES: The associations among retinal vascular parameters with glaucoma, the main glaucoma subtype primary open-angle glaucoma (POAG), and ocular hypertension (OHT).
RESULTS: A total of 123 persons (4.4% of the 2789 participants) had glaucoma in the final analysis, 87 (70.7%) of whom were diagnosed with POAG. After adjusting for age, sex, body mass index, diabetes, hypertension, smoking, axial length, and intraocular pressure (IOP), decreased retinal arteriolar tortuosity (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.38-2.18, comparing lowest vs. highest quartiles), decreased retinal venular tortuosity (OR, 1.59; 95% CI, 1.29-1.97), and narrower retinal venular branching angle (OR, 1.22; 95% CI, 1.00-1.48) were associated with glaucoma. Similar associations were found between these retinal vascular parameters and POAG. Decreased retinal vascular fractal dimension was associated with OHT (OR 1.37; 95% CI, 1.04-1.82).
CONCLUSIONS: Certain features of retinal vascular geometry are associated with glaucomatous optic neuropathy independently of vascular risk factors and IOP.
FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.