Journal of neuroradiology = Journal de neuroradiologie · 2012
Reduced white matter integrity in primary open-angle glaucoma: a DTI study using tract-based spatial statistics.
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Lu Peigang, Shi Linping, Du Hanjian, Xie Bing, Li Changying, Li Sha, Liu Ting, Feng Hua, Wang Jian
Аннотация
BACKGROUND AND PURPOSE: The present study was designed to map the alteration of white matter in primary open-angle glaucoma (POAG) by applying tract-based spatial statistics (TBSS) analysis.
METHODS: Diffusion tensor imaging (DTI) data from MRI brain scans were collected from 15 POAG patients and 15 gender- and age-matched non-glaucoma controls using a SIEMENS Trio 3.0-Tesla scanner. For the white-matter analysis, DTI images were processed using FSL software (http://www.fmrib.ox.ac.uk/fsl/index.html). Fractional anisotropy (FA) between the POAG and control groups was compared by TBSS analysis corrected for multiple comparisons using threshold-free cluster enhancement (TFCE).
RESULTS: Compared with non-glaucoma subjects, the occipital white matter in POAG patients had significantly lower FA values (p<0.05, corrected).
CONCLUSION: The change in white-matter FA may indicate atrophy of the visual cortex that may be important in the diagnosis and treatment of POAG patients.
METHODS: Diffusion tensor imaging (DTI) data from MRI brain scans were collected from 15 POAG patients and 15 gender- and age-matched non-glaucoma controls using a SIEMENS Trio 3.0-Tesla scanner. For the white-matter analysis, DTI images were processed using FSL software (http://www.fmrib.ox.ac.uk/fsl/index.html). Fractional anisotropy (FA) between the POAG and control groups was compared by TBSS analysis corrected for multiple comparisons using threshold-free cluster enhancement (TFCE).
RESULTS: Compared with non-glaucoma subjects, the occipital white matter in POAG patients had significantly lower FA values (p<0.05, corrected).
CONCLUSION: The change in white-matter FA may indicate atrophy of the visual cortex that may be important in the diagnosis and treatment of POAG patients.
Предметные рубрики MeSH
AdolescentAdultAgedAlgorithmsData Interpretation, StatisticalDiffusion Tensor ImagingFemaleGlaucoma, Open-AngleHumansImage EnhancementImage Interpretation, Computer-AssistedMaleMiddle AgedNerve Fibers, MyelinatedOccipital LobeReproducibility of ResultsSensitivity and SpecificityVisual CortexYoung Adult