The Israel Medical Association journal : IMAJ · 2021
Tumor-like Lesions in Patients with Granulomatosis with Polyangiitis: A Case Series.
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Gendelman Omer, Kuntzman Yuval, Shovman Ora, Langevitz Pnina, Tsur Avishai M, Erez Daniel, Levy Yair, Amital Howard
Аннотация
BACKGROUND: Granulomatosis with polyangiitis (GPA) is a rare small vessel vasculitis. It usually involves the respiratory tract and kidney. Rarely, tumor-resembling inflammatory changes ensue.
OBJECTIVES: To report three unique cases of GPA presenting with tumor-like lesions in various organs.
METHODS: We presented three cases of GPA. Case 1 presented with typical upper respiratory symptoms of GPA and a mediastinal mass. Case 2 presented with low back pain, a large retroperitoneal mass, and nodular skin lesions. Case 3 presented with epigastric pain and a paravertebral inflammatory mass.
RESULTS: The patients were treated successfully with rituximab.
CONCLUSIONS: Clinicians should be aware of this presentation of granulomatosis with polyangiitis, which is known as Tumefaction Wegener's granulomatosis.
OBJECTIVES: To report three unique cases of GPA presenting with tumor-like lesions in various organs.
METHODS: We presented three cases of GPA. Case 1 presented with typical upper respiratory symptoms of GPA and a mediastinal mass. Case 2 presented with low back pain, a large retroperitoneal mass, and nodular skin lesions. Case 3 presented with epigastric pain and a paravertebral inflammatory mass.
RESULTS: The patients were treated successfully with rituximab.
CONCLUSIONS: Clinicians should be aware of this presentation of granulomatosis with polyangiitis, which is known as Tumefaction Wegener's granulomatosis.
Предметные рубрики MeSH
AdultAntibodies, Antineutrophil CytoplasmicBiomarkersBiopsyDiagnosis, DifferentialFemaleGranulomaGranulomatosis with PolyangiitisHumansImmunosuppressive AgentsKidney NeoplasmsMagnetic Resonance ImagingMaleMediastinal NeoplasmsMiddle AgedMyeloblastinRetroperitoneal NeoplasmsRituximabTomography, X-Ray ComputedTreatment Outcome