Development of spontaneous autoimmune thyroiditis in Obese strain (OS) chickens.

Chickens of the Obese strain (OS) are known to develop spontaneous autoimmune thyroiditis (SAT) in the first 2-3 weeks post-hatching, but onset and severity of SAT for this period among sublines of OS chickens has not yet been analysed in detail. In the present paper, we described the kinetics of SAT in age-matched OSB13B13C, OSB5B5C, OSB15B15INN and OSB5B5INN chicken sublines. The results revealed no thyroid infiltration in OS fetuses at 20th ED of the analysed sublines. Mononuclear cell infiltration of thyroid was first noted in 2-4-day-old chickens, followed by aggravation of thyroiditis in 4-week-old OSB13B13C and OSB15B15INN chickens and in 5-week-old OSB5B5C birds. Interestingly, two subpopulations of OSB5B5INN chickens were found with different kinetics of SAT development: one with degree of SAT lower than 40%, was designated "low responders" and the other, with similar degrees of SAT as the other three sublines, was characterized as "high responders". Our results allow an age-dependent prediction of SAT development among OS chickens and the rational design of animal experiments, particularly for assessing the relevance of therapeutic interventions.