JACC. Cardiovascular interventions · 2026
Atrial Fibrillation and Tricuspid Regurgitation in Patients Undergoing Mitral Valve Transcatheter Edge-to-Edge Repair.
СтатьяНазвание и аннотация: Перевод в очереди
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Matsumoto Shingo, Ohno Yohei, Noda Satoshi, Miyamoto Junichi, Kamioka Norihiko, Murakami Tsutomu, Ikari Yuji, Kubo Shunsuke, Izumi Yuki, Saji Mike, Yamamoto Masanori, Asami Masahiko, Enta Yusuke, Shirai Shinichi, Izumo Masaki, Mizuno Shingo, Watanabe Yusuke, Amaki Makoto, Kodama Kazuhisa, Otsuki Hisao, Naganuma Toru, Bota Hiroki, Yamawaki Masahiro, Ueno Hiroshi, Nakazawa Gaku, Hachinohe Daisuke, Otsuka Toshiaki, Hayashida Kentaro, OCEAN-Mitral Investigators
Аннотация
BACKGROUND: The interplay between atrial fibrillation (AF) and tricuspid regurgitation (TR) has been recognized. However, it is not simple and has not been fully investigated.
OBJECTIVES: The aim of this study was to examine the association among AF, TR, and outcomes in patients undergoing mitral valve transcatheter edge-to-edge repair (M-TEER).
METHODS: Patients were divided into 4 groups according to the presence of AF and postprocedural significant TR (moderate or greater): no AF and no TR, no AF with significant TR, AF and no TR, and AF with significant TR. The primary outcome was cardiovascular death or heart failure (HF) hospitalization. Right heart structure and function were also evaluated according to AF and TR status.
RESULTS: The numbers of patients in each group were 1,184 (no AF and no TR), 229 (no AF with significant TR), 1,423 (AF and no TR), and 830 (AF with significant TR). AF was associated with a higher prevalence of significant TR at baseline and more frequent TR progression and less common improvement during follow-up. Both AF and TR appeared to be independently associated with right-ventricular remodeling and dysfunction, with distinct patterns observed according to MR and TR pathologies. TR grade moderate or greater after M-TEER was associated with a higher adjusted risk for cardiovascular death or HF hospitalization, especially in patients with AF (Pinteraction = 0.02).
CONCLUSIONS: Patients with AF, compared with those without AF, experienced greater incidence and progression and less common improvement of TR after M-TEER. In addition, both AF and TR appeared to be independently associated with worse right ventricular status and an increased risk for HF outcomes.
OBJECTIVES: The aim of this study was to examine the association among AF, TR, and outcomes in patients undergoing mitral valve transcatheter edge-to-edge repair (M-TEER).
METHODS: Patients were divided into 4 groups according to the presence of AF and postprocedural significant TR (moderate or greater): no AF and no TR, no AF with significant TR, AF and no TR, and AF with significant TR. The primary outcome was cardiovascular death or heart failure (HF) hospitalization. Right heart structure and function were also evaluated according to AF and TR status.
RESULTS: The numbers of patients in each group were 1,184 (no AF and no TR), 229 (no AF with significant TR), 1,423 (AF and no TR), and 830 (AF with significant TR). AF was associated with a higher prevalence of significant TR at baseline and more frequent TR progression and less common improvement during follow-up. Both AF and TR appeared to be independently associated with right-ventricular remodeling and dysfunction, with distinct patterns observed according to MR and TR pathologies. TR grade moderate or greater after M-TEER was associated with a higher adjusted risk for cardiovascular death or HF hospitalization, especially in patients with AF (Pinteraction = 0.02).
CONCLUSIONS: Patients with AF, compared with those without AF, experienced greater incidence and progression and less common improvement of TR after M-TEER. In addition, both AF and TR appeared to be independently associated with worse right ventricular status and an increased risk for HF outcomes.
Предметные рубрики MeSH
HumansTricuspid Valve InsufficiencyAtrial FibrillationMitral Valve InsufficiencyFemaleRisk FactorsMaleCardiac CatheterizationAgedTreatment OutcomeTime FactorsMitral ValveVentricular Function, RightAged, 80 and overHeart FailureRecovery of FunctionHeart Valve Prosthesis ImplantationPrevalenceVentricular RemodelingRetrospective StudiesDisease Progression