[Comparative gastroscopic and pathologic study on "one point carcinoma" in gastric cancer--analysis of 25 cases. "One Point Carcinoma" National Cooperative Group].

Twenty-five cases of "one point carcinoma" of the stomach, collected from 14 institutes in China, diagnosed by gastroscopic biopsy and proved by regional serial sectioning of the resected specimen as having no more cancerous lesion are presented and studied. The concept, terminology and significance of "one point carcinoma" on the gastric mucosa are put forward by comparative study of the local gross findings and the histopathologic features. The gastroscopic findings showed: mucosal discoloration 3 cases; nodule-like elevation 8 cases; superficial erosion 6 cases; and superficial ulceration 8 cases. Pathologic diagnosis of mucosal biopsy material was: well and moderately differentiated adenocarcinoma 11 cases; poorly differentiated adenocarcinoma 4 cases; signet-ring cell carcinoma 1 case; cancerous change 4 cases; and carcinoma unclassifiable 3 cases. The pathologic changes in the gastric mucosa of the resected specimen were: chronic atrophic gastritis, intestinal metaplasia with superficial erosion and dysplasia 14 cases; superficial gastritis (including partial gastritis verrucosa), intestinal metaplasia with superficial erosion, superficial ulceration and dysplasia 11 cases. The concept of "one point carcinoma", its gross characteristics, biopsy technique and observations as well as other relevant problems discussed are important in the detection of micro-cancerous lesion of gastric carcinoma.