[Clinical and endoscopic characteristics of duodenal ulcer in patients from the Tis River region from the aspect of functional status of the gastric mucosa and therapeutic effects].

A group of 300 patients with peptic ulcers was formed by the method of accidental choice and consists of 252 males (84.00%) and 48 females (16.00%) with a ratio between sexes of 5.25:1 in favor of the male sex. Out of risk factors of the disease, the most frequent ones were the caffeine beverage (in 69.66% of patients) and smoking (in 67.0% of all examined subjects). Laboratory findings were of no greater significance in the diagnostics of peptic ulcer, while radiological examination verified ulcers of this location in 43.33% of patients. By means of endoscopic examination a defect of duodenal mucosa was visualized in 100% of patients and this was most frequently seen on the anterior wall of the bulb (60.33%), small ulcerations up to 0.5 mm in diameter (in 55.0% of cases). Different forms of chronic atrophic gastritis were determined in 48.00% of patients by means of pathohistological expert opinion, and chronic enteritis was the fact in 71.66% of patients. In duodenal ulcer therapy, the best results were achieved with preparations of the third generation of H2 antagonists (complete reepithelialization in 94.00% of cases H2 = 38.72, p less than 0.001), and with omeprazol (healing of ulcer in 98.00% of patients, H2 = 68.50, p less than 0.001).