The roles of extracranial intravascular lesion, vasodilation-induced neural entrapment, and arteriolysis in migraine treatment.

The few available studies of biopsies performed during migraine surgery have revealed intravascular changes of the occipital and superficial temporal arteries. It is not clear whether these abnormalities are purely of local origin or of systemic nature. This letter discusses possible associations between extracranial vascular alterations and vasodilatory neural entrapment. Exploration of spatial differences in vascular morphology of the involved arteries could provide further insights.