Revista espanola de enfermedades digestivas · 2025
Incidence and delayed diagnosis of hepatitis C: unexpected findings in times of elimination.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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История · было → стало
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Torres Martel Esteban Gabriel, Hernández-Febles Melisa, Serrano Fuentes Miriam, Labrador Vázquez Blas, Zaragozá González Raquel, Granados Monzón Rafael, Quiñones Morales Ildefonso, Bordes Benítez Ana, Pena López María José
Аннотация
INTRODUCTION: Chronic hepatitis C virus (HCV) infection remains a public health concern. Late diagnosis and barriers to treatment hinder progress toward elimination goals. In Spain, although prevalence has declined, a hidden burden of infection persists. This study analyzes the incidence of newly diagnosed HCV cases in a region of Gran Canaria during 2023-2024, the frequency of late presentation, and access to antiviral treatment.
PATIENTS AND METHODS: Clinical-epidemiological, observational, descriptive, and retrospective study of newly diagnosed hepatitis C patients, whether identified through clinical request or opportunistic screening. "Late presentation" was defined as fibrosis ≥F3.
RESULTS: A total of 87 cases were diagnosed (13.2 and 11.1 per-100,000 people in 2023 and 2024, respectively): 69 chronic cases (79.3%) and 18 acute cases (20.7%, with 38.9% reinfections). Among chronic hepatitis cases, 50.8% presented late, with a 1-year mortality of 11.6%. Screening led to diagnosis in 34.5% of cases, and more than 30% of chronic cases had no identifiable risk factors. Acute infections predominantly affected HIV-positive men who have sex with men (88.9%). Direct referral from the laboratory enabled most patients to access treatment within one year.
CONCLUSIONS: In this descriptive, and retrospective study, the incidence of new HCV diagnoses exceeds the WHO elimination targets, with a high proportion of late-stage diagnoses and active transmission amongst vulnerable populations. There is a need to intensify screening strategies, optimize care coordination, and strengthen preventive interventions.
PATIENTS AND METHODS: Clinical-epidemiological, observational, descriptive, and retrospective study of newly diagnosed hepatitis C patients, whether identified through clinical request or opportunistic screening. "Late presentation" was defined as fibrosis ≥F3.
RESULTS: A total of 87 cases were diagnosed (13.2 and 11.1 per-100,000 people in 2023 and 2024, respectively): 69 chronic cases (79.3%) and 18 acute cases (20.7%, with 38.9% reinfections). Among chronic hepatitis cases, 50.8% presented late, with a 1-year mortality of 11.6%. Screening led to diagnosis in 34.5% of cases, and more than 30% of chronic cases had no identifiable risk factors. Acute infections predominantly affected HIV-positive men who have sex with men (88.9%). Direct referral from the laboratory enabled most patients to access treatment within one year.
CONCLUSIONS: In this descriptive, and retrospective study, the incidence of new HCV diagnoses exceeds the WHO elimination targets, with a high proportion of late-stage diagnoses and active transmission amongst vulnerable populations. There is a need to intensify screening strategies, optimize care coordination, and strengthen preventive interventions.