[P300 potential parameters at the stages of formation of the subcortical vascular dementia in elderly].

Auditory P300 latency and amplitude values were assessed in 11 elderly persons without cognitive impairments (WCI), mean age--(70.73 +/- 4.24) years, 20 patients with subcortical vascular mild cognitive impairment (SCMCI), mean age--(75.35 +/- 5.48) years and 20 patients with subcortical vascular dementia (SCVaD), mean age (75.80 +/- 6.51) years. Obtained data suggest that P300 latency value increase at the stages of the SCVaD progression. Mean values of P300 latency were (341.09 +/- 107.70) ms in WCI group, (655.70 +/- 87.08) ms in SCMCI patients, (732.45 +/- 74.64) ms in SCVaD patients. There were significant differences between the groups. This parameter allows differentiating patients with SCMCI from elderly persons WCI, and patients with SCVaD from SCMCI. Increasing P300 latency has sufficient relationship to severity and specificity of cognitive deficit of SCVaD stages development reflecting progressive deterioration of attention, working memory, kinetic and regulator praxis.