Iranian journal of public health · 2021
Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto's Thyroiditis.
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Esfahanian Fatemeh, Hazaveh Mojgan Mirabdolhagh, Garehbagh Laya Hooshmand, Falahati Kowsar, Ataei Mitra, Sanati Mohammad Hossein, Jadali Zohreh
Аннотация
BACKGROUND: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy controls (HC).
METHODS: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto's thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018.
RESULTS: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group.
CONCLUSION: These data suggest the possible involvement of mitochondria and oxidative stress in the pathophysiology of HT.
METHODS: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto's thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018.
RESULTS: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group.
CONCLUSION: These data suggest the possible involvement of mitochondria and oxidative stress in the pathophysiology of HT.